Many studies supported that bone marrow mesenchymal stem cells (BM-MSCs) can differentiate into neural cells, but few researchers detected mature and function of nerve cells, especially in vivo study.Some researchers even 2006 nissan altima radio suggested that BM-MSCs transplantation would not be able to differentiate into functional neural cells.To figure out the dispute, this study examined bone marrow-derived sphere-like cells, harvested via neural stem cell suspension culture, then identified as bone marrow-derived neural progenitor cells (BM-NPCs) by finding the expression of neural progenitor cells genes and proteins, neural progenitor cells characteristic and nerve cell differentiation induced through both methods.
Moreover, BM-NPCs transplantation showed long-term survival and improved the ethological and histological indexes read more of brain injury rats, demonstrating functional nervous cells differentiated from BM-NPCs.These in vitro and in vivo results confirmed BM-NPCs differentiating into mature and functional nerve cells.This study provided valuable experimental data for BM-NPCs, suggesting a potential alternative treatment of central nervous injury disease.